5-aza-2’-deoxycytidine (DAC) treatment induces the MAGE-A10 expression and improves the cytotoxicity of MAGE-A10-specific CTLs in lung cancer cells
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چکیده
منابع مشابه
Suppression of MAGE-A10 alters the metastatic phenotype of tongue squamous cell carcinoma cells
MAGE-A10 is a member of the MAGE protein family (melanoma associated antigen) which is overexpressed in cancer cells. Although MAGE-A10 has been characterized for some time and is generally associated to metastasis its function remains unknown. Here we describe experiments using as models oral squamous cell carcinoma (OSCC) cell lines displaying increasing metastatic potential (LN1 and LN2). Th...
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Immunotherapy is being proposed to treat patients with hepatocellular carcinoma (HCC). However, more detailed knowledge on tumor Ag expression and specific immune cells is required for the preparation of highly targeted vaccines. HCC express a variety of tumor-specific Ags, raising the question whether CTL specific for such Ags exist in HCC patients. Indeed, a recent study revealed CTLs specifi...
متن کاملExpression and prognostic relevance of MAGE-A3 and MAGE-C2 in non-small cell lung cancer
Melanoma-associated antigen (MAGE)-A3 and MAGE-C2 are antigens encoded by cancer-germline genes, and have been recognized as potential prognostic biomarkers and attractive targets for immunotherapy in multiple types of cancer. The present study aimed to analyze the clinicopathological significance of MAGE-A3/C2 expression in non-small cell lung cancer (NSCLC). The association between MAGE-A3/C2...
متن کاملMelanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants.
PURPOSE The melanoma-associated antigens (MAGEs) are tumor-specific antigens recognized by cytotoxic T lymphocytes. In this study, expression of MAGE family A members was evaluated during the development of esophageal adenocarcinoma (EA) as potential targets for immunotherapy. EXPERIMENTAL DESIGN MAGE-A mRNA expression was evaluated in 46 samples including Barrett's metaplasia (BM), dysplasia...
متن کاملInduction of MAGE-3 expression in lung and esophageal cancer cells.
BACKGROUND Although MAGE-3 has been detected in approximately 40% of lung and esophageal cancers, expression of this cancer testis antigen appears to be below the threshold for immune recognition in patients with these malignancies. The aim of this study was to determine if the demethylating agent, 5-Aza-2'-deoxycytidine (DAC) and if the histone deacetylase inhibitor Depsipeptide FR901228 (DP) ...
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ژورنال
عنوان ژورنال: Translational Cancer Research
سال: 2020
ISSN: 2218-676X,2219-6803
DOI: 10.21037/tcr.2020.01.10